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KMID : 0380219940270040346
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Journal of Biochemistry and Molecular Biology
1994 Volume.27 No. 4 p.346 ~ p.349
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Correlation Between Superoxide Radical Production and Hepatic Damage Induced by Bile Duct Ligation
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Abstract
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Abstract:
@EN The correlation between superoxide radical production and hepatic damage under cholestasis induced by common bile ducr(CBD) ligation was studied in rats. The amount of superoxide radical production in the cholestatic liver was significantly
increased after CBD ligation compare to a sham operation control group. Serum and cytosolic xanthine oxidase (SO) activites were significantly increased after operation, Serum alanine aminotransferase(ALT), aspartate aminotransferase (AST), and
alkaline
phosphatase (ALP) activities, and the bilirubin level of the cholestatic liver in the subject rats increased after CBD ligation. Severe morphological changes were also noted after CBD ligation. These parameters, which are known to reflect hepatic
function in the serum, and the XO activity were significantly correlated with the amount of superoxide radical production. According to these results an increased XO activity includes an increased conversion from xanthine dehydrogenase in the
liver,
resulting in an increase in oxygen free radical production. These oxygen radicals may play a role in the aggrevation of inflammation and necrosis in the liver under cholestasis induced by CBD ligation.
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KEYWORD
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